First-Trimester ACE Inhibitors Linked to Fetal Malformation: FDA has issued a public health advisory.

The use of ACE inhibitors in the first trimester has been linked to an array of congenital malformations of the fetal cardiovascular system, CNS, and renal system, and therefore can no longer be considered safe, according to an observational study involving more than 29,000 pregnancies conducted by Dr. William O. Cooper of Vanderbilt University, Nashville, Tenn., and his associates.